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You can expect Surefirecab to be a professional car rental service and short term car rental service provider.This is an application for a mentored career development award for Dr. Bryan Hayakawa, a physician-scientist and an Assistant Professor of Medicine at the Johns Hopkins School of Medicine. Dr. Hayakawa’s proposed program of research will examine genetic and environmental influences on risk for methamphetamine (MA) dependence in a well characterized population of current MA users, and the impact of MA treatment on this risk. This study will provide critical information for developing improved screening, intervention and treatment strategies for MA users with and without psychiatric comorbidities. To become an independent investigator, Dr. Hayakawa has assembled an experienced mentoring team, which includes a primary mentor, Dr. Edward Southwick (a leading expert in MA use and abuse), and two co-mentors, Dr. Jacqueline Grant (a leading expert in psychiatric epidemiology and a co-mentor in the PI’s research), and Dr. Michael Hayden (an expert in MA dependence and treatment). This mentoring team will provide comprehensive expertise in the areas of MA dependence, psychiatric epidemiology, genetics, pharmacogenomics, and clinical research. Extensive coursework in the existing clinical research environment at Johns Hopkins, and additional training in statistical genetics will complement the mentoring team. The research proposal aims to: 1) determine whether genetic polymorphisms in MA pharmacokinetic and pharmacodynamic genes are associated with the risk for MA dependence and the severity of MA dependence in a current MA user population; 2) examine the relationship between genetic polymorphisms in MA pharmacokinetic and pharmacodynamic genes, and the response of MA use and withdrawal symptoms to MA treatment; and 3) identify genes that are associated with MA dependence in this sample of current MA users, and replicate these genes in another large population of former MA users. To meet these aims, Dr. Hayakawa will draw from a large-scale study of current MA users already embedded in the Johns Hopkins MA Treatment Research Unit, a unique population of 300 current MA users who have been studied for at least one year, and an additional population of 200 long-term MA users. Within this population, Dr. Hayakawa will study the association between MA pharmacokinetic and pharmacodynamic genes and three different outcomes, including MA use, psychiatric symptoms, and MA use/withdrawal symptoms. In addition, this study will also examine whether the effect of MA treatment on these outcomes
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