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Your rating: None 0 0 votes!. Please read the «CONDITIONS OF USE» before downloading this file.Methadone pharmacokinetics in children after 1 day of dosing.
To establish methadone pharmacokinetic profiles in children, with particular attention to the role of age, weight, and dialysate flow rate on methadone clearance. We administered methadone hydrochloride (Dolophine; Abbott Laboratories, North Chicago, IL) at increasing doses, starting with 0.10 mg/kg/d over 5 days and increasing dose by 0.05 mg/kg every 5 days to a maximum dose of 0.40 mg/kg/d, to 14 children aged 1.4-12.8 years (mean age, 5.7+/-3.5; SD) with end-stage renal disease, in an open-label, randomized, two-period crossover study. Serum methadone concentrations were measured by gas chromatography-mass spectrometry. Dose-normalized clearance ranged from 0.027 to 0.070 L/min/kg (40-100 mL/min/1.73 m(2)). Body weight was a better predictor of methadone clearance than age. Methadone clearance was not statistically significantly different for any age stratum. Pediatric patients with end-stage renal disease, who had a small number of unusually low clearances, may show age-related variability in methadone clearance, but differences that are not statistically significant. For any age stratum, a dialysate flow rate of 500 mL/min should be used to optimize methadone clearance in children.Q:
Joomla 2.5: Including/Extending controllers or model files?
Are there any benefits to extending controllers and/or models in Joomla 2.5?
I am currently trying to extend the Joomla core controllers in a project where I am required to customize the core with a new component.
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